Recent research has highlighted the potential of dietary proteins from beans and eggs as sources of antioxidants and antidepressants. These proteins were examined for their effects on mental health using animal models, with a focus on their ability to counter oxidative stress and depressive symptoms.
The study involved undenatured (natural) and denatured (heat-treated) protein extracts at varying concentrations. Antioxidant properties were tested using the DPPH and hydrogen peroxide (H₂O₂) assays. While the DPPH results were inconclusive due to interference from ethanol, the H₂O₂ assay revealed significant antioxidant activity in both types of extracts, particularly those with higher concentrations.
Antidepressant properties were evaluated using two methods: the forced swim test for acute effects and the sucrose preference test for chronic depression. Both undenatured and denatured protein extracts showed promising antidepressant effects, reducing immobility time and increasing sucrose preference in mice. Notably, the 80% concentration extracts performed similarly to standard antidepressant medications.
In terms of toxicity, egg protein extracts were found to be non-toxic even at high doses. In contrast, bean protein extracts showed mild toxicity at higher concentrations (80%), suggesting careful consideration in therapeutic use.
This study underscores the potential of bean and egg proteins as natural agents for managing oxidative stress and depression, paving the way for further exploration of food-based solutions in mental health treatment.
DOI Link: https://dx.doi.org/10.61927/igmin114
Full Text: https://www.igminresearch.com/articles/html/igmin114
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