This study examines how artificially triggering the Unfolded Protein Response (UPR) can enhance the endoplasmic reticulum (ER) in Saccharomyces cerevisiae, also known as baker’s yeast. The ER plays a crucial role in synthesizing and folding proteins, and expanding its capacity can significantly boost the yeast’s ability to produce commercially valuable compounds like secretory proteins and functional lipids.
By inducing the UPR through controlled expression of the Hac1i protein, yeast cells undergo ER expansion without being under stress conditions. This increase in ER size improves the yeast’s production of essential compounds used in biotechnology, such as antibodies, interferons, and lipid-based molecules. However, the study also notes challenges, as unregulated UPR activation can hinder yeast growth, leading to potential productivity issues.
To address this, the researchers propose utilizing a regulated expression system that can boost ER capacity at specific growth phases. This approach allows for the efficient production of valuable substances while maintaining yeast cell health, offering a promising method for improving industrial-scale biotechnological processes.
Full Text: https://www.igminresearch.com/articles/html/igmin142
DOI Link: https://dx.doi.org/10.61927/igmin142
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