A recent study explores the potential link between cholesterol-lowering drugs, particularly statins, and a reduced risk of malignant meningiomas—aggressive brain tumors with limited treatment options. By using Mendelian Randomization (MR) analysis, researchers examined the effects of genetic variants associated with lipid-lowering drug targets on meningioma risk.
This study focuses on four key drug targets: HMGCR, PCSK9, NPC1L1, and APOB. Findings revealed that variants influencing HMGCR, the target of statins, may decrease the risk of malignant meningiomas, while no significant effects were observed for the other drug targets. Elevated expression of the HMGCR gene was linked to a reduced susceptibility to these tumors, suggesting that statins might offer a protective effect.
This research emphasizes the potential of repurposing statins, widely used to manage cholesterol, as a preventive measure for certain cancers. However, further clinical trials are needed to confirm these findings and better understand the mechanisms behind statins’ protective effect.
Full Text: https://www.igminresearch.com/articles/html/igmin187
DOI Link: https://dx.doi.org/10.61927/igmin187
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