This study explores how fibrin enhances wound healing in fibroblast-populated collagen lattices (FPCLs) used as an in vitro model to replicate the body’s natural wound repair mechanisms. In wound healing, fibrin forms a clot that facilitates tissue repair. This study introduces two types of FPCLs: relaxed and stressed, which mimic the mechanical conditions in wounds. Relaxed FPCLs close wounds faster when fibrin is applied, as it helps organize the collagen structure, enhancing wound repair.
In the stressed FPCLs, however, wound closure is delayed due to the high tension on the matrix, which keeps the wound open even with fibrin treatment. This difference reveals that while fibrin can significantly improve wound healing in low-stress environments, excessive tension can counteract its benefits.
By using fibrin in FPCL models, researchers can better understand how wound healing mechanisms respond under different biomechanical conditions, contributing to improved methods in tissue engineering and regenerative medicine. This model provides valuable insights into how fibrin and collagen interact during wound healing, aiding future research on wound repair.
🔗 Full Text: https://www.igminresearch.com/articles/html/igmin159
🔗 DOI Link: https://dx.doi.org/10.61927/igmin159
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