This recent study examines why younger women with diminished oocyte reserve (DOR) experience lower pregnancy rates after IVF, compared to those with a normal oocyte reserve (NOR). While DOR is often associated with older women, younger women with this condition face unique challenges. The research focused on IVF-ET (in vitro fertilization-embryo transfer) outcomes in women under 35, analyzing stages where pregnancy rates drop, from embryo transfer to live birth.
Key findings reveal that the main reduction occurs early, with fewer embryos in the DOR group implanting successfully or achieving a positive pregnancy test compared to the NOR group. This indicates that implantation failure or early embryo demise, potentially linked to genetic abnormalities or low mitochondrial DNA, may be a significant factor in reduced pregnancy rates among women with DOR.
With these insights, the study suggests that adjusting IVF protocols, like using FSH receptor up-regulation techniques, could improve outcomes for younger women with DOR. This research is valuable for healthcare providers and patients, particularly those exploring alternatives like donor eggs.
Full Text: https://www.igminresearch.com/articles/html/igmin188
DOI Link: https://dx.doi.org/10.61927/igmin188
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