This study examines an alternative approach to minimize rectal toxicity in prostate cancer patients undergoing radiotherapy. Typically, rectal toxicity impacts about 25% of prostate cancer patients, leading to discomforts like diarrhea, bowel urgency, and incontinence. Traditionally, patients rely on enemas or rectal spacers to prevent toxicity. However, this study proposes a non-invasive approach using a fiber- and fat-free diet combined with activated charcoal and macrogol supplements.
Methodology
The study monitored 115 patients receiving 70.2 Gray radiation through Volumetric Modulated Arc Therapy (VMAT). Patients followed a strict diet, and those with eating disorders were given activated charcoal and macrogol. By comparing CT scans of the rectum before and during treatment, researchers assessed rectal positioning and toxicity levels.
Results
Patients on diet alone experienced a 20% rate of rectal toxicity, while those with added supplements showed a dramatic reduction to only 1% acute toxicity. This approach not only minimized toxicity but also improved patient comfort during treatment, eliminating the need for invasive spacers.
Conclusion
Diet combined with activated charcoal and macrogol presents a promising non-invasive method to reduce rectal toxicity in prostate cancer treatment. This alternative offers a patient-friendly option, potentially improving quality of life and treatment outcomes.
🔗 Full Text: https://www.igminresearch.com/articles/html/igmin161
🔗 DOI Link: https://dx.doi.org/10.61927/igmin161
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